Oral Squamous Papilloma, Multiply Recurrent, in a Patient With Psoriasis Receiving the Tumor Necrosis Factor Alpha Antagonist Adalimumab

Tumor necrosis factor alpha (TNF?) is a cytokine secreted by macrophages that regulates various biologic processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Increased TNF? has been implicated in autoimmune diseases, insulin resistance, and cancer. TNF? antagonists are known to cause reactivation of many bacterial and viral infections. Adalimumab is a monoclonal antibody that neutralizes TNF? activity and induces complement-mediated cell lysis of mononuclear cells expressing TNF?. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Source: http://www.medworm.com/index.php?rid=7778407&cid=u_0_16_f&fid=36644&url=http%3A%2F%2Fwww.oooojournal.net%2Farticle%2FS2212-4403%2813%2900575-0%2Fabstract%3Frss%3Dyes

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