Human CLOCK gene-associated attention deficit hyperactivity disorder-related features in healthy adults: quantitative association study using Wender Utah Rating Scale.

Authors: Jeong SH, Yu JC, Lee CH, Choi KS, Choi JE, Kim SH, Joo EJ
Abstract
Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as the extreme end of a continuously distributed trait that can be found in the general population. Therefore, we examined two possibilities: (1) an ADHD-related continuous trait may be associated with the CLOCK gene, and (2) this association may be mediated by the degree of individuals' evening preference. To explore these possibilities, we performed a quantitative trait locus association study wi...

Source: http://www.medworm.com/index.php?rid=7632028&cid=u_0_172_f&fid=39392&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24068320%3Fdopt%3DAbstract

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