Gene-Environment Interaction of Body Mass Index and Apolipoprotein E ?4 Allele on Cognitive Decline.

Authors: Rajan KB, Skarupski KA, Rasmussen HE, Evans DA
Abstract
Genetic variation alone may not account for common chronic disease susceptibility. Rather, an interaction between genetic and environmental factors may clarify the underlying disease mechanism. Hence, we tested whether body mass index (BMI) modified the genetic association of the apolipoprotein E ?4 allele with cognitive decline. The data came from a longitudinal population-based sample of 4055 participants interviewed at 3-year intervals from 1993 to 2012. Cognitive function was assessed using a standardized global cognitive score and BMI was assessed at baseline and classified as normal, overweight, and obese. There were 1374 (34%) participants with the ?4 allele. In normal BMI participants, cognitive decline was ...

Source: http://www.medworm.com/index.php?rid=7699150&cid=u_0_172_f&fid=39378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24145695%3Fdopt%3DAbstract

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