Amyloid PET Imaging in Lewy Body Disorders.

Authors: Donaghy P, Thomas AJ, O'Brien JT
Abstract
Lewy body (LB) disorders, including Parkinson disease (PD), Parkinson disease dementia (PDD), and dementia with Lewy bodies (DLB), are the second most common type of neurodegenerative dementia. Although the pathological hallmarks of LB disorders are Lewy bodies and Lewy neurites, cortical amyloid-beta (A?) deposition is also often seen. The relationship between A? pathology and dementia in LB disorders is unclear. Recently, positron emission tomography A? ligands have been developed that enable in�vivo imaging of A?. In this paper we review amyloid imaging studies in LB disorders. LB disorders are associated with lower mean cortical A? ligand binding compared with Alzheimer disease. In DLB and PDD many subjects have normal le...

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