Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c.

Authors: Nili M, David L, Elferich J, Shinde U, Rotwein P
Abstract
HJV (haemojuvelin) plays a key role in iron metabolism in mammals by regulating expression of the liver-derived hormone hepcidin, which controls systemic iron uptake and release. Mutations in HJV cause juvenile haemochromatosis, a rapidly progressing iron overload disorder in humans. HJV, also known as RGMc (repulsive guidance molecule c), is a member of the three-protein RGM family. RGMs are GPI (glycosylphosphatidylinositol)-linked glycoproteins that share ~50% amino acid identity and several structural motifs, including the presence of 14 cysteine residues in analogous locations. Unlike RGMa and RGMb, HJV/RGMc is composed of both single-chain and two-chain isoforms. To date there is no structural information for ...

Source: http://www.medworm.com/index.php?rid=7258126&cid=u_0_60_f&fid=37584&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23464809%3Fdopt%3DAbstract

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