[Comment] Genetics of warfarin dosing?one polymorphism at a time

Few drugs define a narrow therapeutic index better than warfarin. With a typical therapeutic international normalised ratio (INR) of 2�0?3�0 for most indications (2�5?3�5 for mechanical heart valves), clinicians are challenged to define and implement dosing regimens that achieve therapeutic anticoagulation. The stakes could hardly be higher: too low a dose places the patient at an increased risk of a life-altering ischaemic event (ie, stroke or pulmonary embolism); and too high a dose can lead to a fatal cerebral or gastrointestinal haemorrhage. (Source: LANCET)

Source: http://www.medworm.com/index.php?rid=7548676&cid=u_0_22_f&fid=30418&url=http%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flancet%2Farticle%2FPIIS0140-6736%2813%2960942-3%2Ffulltext%3Frss%3Dyes

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