Strain dependence of diet?induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype

ConclusionsIn mice with equivalent genetic/dietary obesity, NASH development is linked to strain differences in hyperinsulinemia and hyperglycemia inversely related to lipid partitioning between adipose and liver. Diabetes?mediated CTGF?regulation of MMPs as well as cytokines/growth factors (Th?2 cytokine predominant, PDGF?, not TGF??) mobilized in the resultant hepatic necroinflammatory change may contribute to strain differences in NASH fibrosis.This article is protected by copyright. All rights reserved. (Source: Liver International)

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