FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas.

Authors: Liu WN, Lin JH, Cheng YR, Zhang L, Huang J, Wu ZY, Wang FS, Xu SG, Lin WP, Lan WB, Yang GX
Abstract
The mTOR pathway is a central control of cell growth, proliferation, metabolism, and survival, and is deregulated in most cancers. Cancer cells are addicted to increased activity of mTOR kinase-mediated signaling pathways, leading to numerous inhibitors of mTOR signaling in preclinic and clinical trials for cancer therapy. Phosphorus-containing sirolimus (FIM-A), which targets mTOR signaling, inhibits cancer cell growth in vitro. Here we report that FIM-A reduces the angiogenesis and proliferation of osteosarcoma both in vitro and in vivo. In cultured osteosarcoma cell lines, FIM-A inhibited cell proliferation and arrested cells in the G1 phase of the cell cycle, accompanied...

Source: http://www.medworm.com/index.php?rid=7457011&cid=u_0_6_f&fid=36638&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23879172%3Fdopt%3DAbstract

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